6433 pts · May 14, 2020
He came to my middle school to do a reading dressed up like Shakespeare with a feather in his hat and everything and our class absolutely talked shit about him after he left. I ended up with a signed copy of the book and the feeling I had just met the nerdiest kid ever. I remember highlighting misspellings in the books and being very let down by the whole series.
He’s talking about age of majority, or the age you’re legally considered an adult, as opposed to age of consent. In most US states you’re legally considered an adult at 18, though there’s a few random states where it’s 19 or higher. I believe age of consent just applies to sex/marriage and I think is 16 in most US states.
My dad used to come home from work and yell out “where’s my sous chef?” I’d haul a chair over to the stove to stand on and we’d cook dinner together. He passed his love language of food on to me. He still calls me to share new recipes and drags me into the kitchen first thing when we go visit.
I was going to say do white uppers and dark lowers to let the white add vibrancy and openness but also add contrast. We had deep blue lowers and white wall open upper shelves in our last kitchen and it was gorgeous.
That hospital would not have accepted that unless someone rocked up with the paperwork to back it up. The EMT/paramedics I used to work with used to say that they wouldn’t follow a DNR tattoo encountered in the wild because it’d too much of a gray area.
The last time I did CPR we saved a 92/93 year old man who was a full code per policy because they couldn’t confirm the DNR status. His POA didn’t show up with any documentation of what he wanted until after we’d coded him for an hour and got him back and in the ICU. It wasn’t what he wanted. I have never been more devastated at work, that shift wrecked me for a while. Frankly harder than all the folks we couldn’t save.
Pair that with some pearl clutching from Susan Collins and we may be in business
I’m sorry, the car driving her to the hospital caught fire? So she was shot in the back by her partner and then the transport car caught on fire. But it was all “unintentional”. Uhhh
Ours flies year round and was ironed by Mother Nature as god intended
There was an uproar when that guy got dumped on Love is Blind because he’d spent the entire series saying he’d “never thought about it” to things like BLM, women’s rights, LGBTQ+ issues etc and he lived in Minneapolis during/after the murder of George Floyd, the fiancé who dumped him has a sibling in the LGBTQ+ crew, he was super into his church, etc. I could never decide if he actually never thought about stuff or if he was hiding it but either way, it’s a whole ass non-starter.
The Dark Crystal. The Skeksis-is (Skesisi?) were the stars of the recurring nightmare I had throughout my entire childhood until I was in college.
As a resident of the ocean edge of Washington state, it would take me 45 Freedom Hours one-way without stopping to drive to DC. I would absolutely march my ass all the way to the gates of the White House if it wasn’t so bloody complicated and time-consuming to get there, especially when there’s such good work going on locally that I can dig in to and support.
My favorite interaction was with a nurse at the health center of Christian university. She decided the appropriate way to ask if I was sexually active was to go with “Is your vagina a penis-free environment?” and my dumb ass went full pikachu face before responding with “In this exact moment or ever?” No the follow-up questions did not go any better 😂
As someone who works on the NIH’s drug research projects, particularly their vaccine -‘d infectious disease work, fuck all of the latest NIH/CDC/FDA updates. Just throw the whole fucking lot out. These people are going to get people killed.
My mom did WW in the early 00s (not that she needed it) and I remember boxes of crackers and cereal being labeled in sharpie with their point values and her trying to convince herself that low fat ricotta with unsweetened cocoa powder was a solid alternative to ice cream. She left that behind shortly after and has never looked back. The obsessive point counting was not good for her.
No me side-eyeing the Rabies study we did that compared a new vaccine to the existing vaccine because no one could reasonably justify having a placebo group https://media2.giphy.com/media/v1.Y2lkPTY1YjkxZmJlZnk4ZzNrOGxwNTB1YWxhOThlYmVtNXdsaXRrbXVodWw3dmZiZGZqaSZlcD12MV9naWZzX3NlYXJjaCZjdD1n/H5C8CevNMbpBqNqFjl/giphy.mp4
Double-blind is the norm, control groups are the norm. It’s that they’re forcing the control group to be placeboes for all vaccines, not just new vaccines. Vaccine research often uses currently approved or similar vaccines as the control group when testing updated vaccines because having a true placebo group would be unethical or because you want to compare the vaccines to each other. Forcing placebo controls for all vaccines changes the game in not a good way.
We tested all of the COVID vaccines before they were given to the general public. And then we kept testing them. And yes, more research gives more data that can confirm safety and efficacy or show things aren’t as good as initial research showed. That’s the purpose of initial phase research and post-approval research. We don’t just stop once things are approved.
Unblinding happens at the end of a study regardless of safety results. I’ve worked on plenty of studies that showed drugs were nothingburgers or not more effective than options already on the market. And that’s okay. That’s the point of research. We keep studying to find safe and effective options for people. But this will actively get in the way of that.
All med research is done with a control group, it’s just that not every control group is placebo because it doesn’t have to be or shouldn’t be (for ethical reasons or based on study design). Updated vaccines are often tested with existing vaccines as the control group instead of placebo. This forces us to test new vaccines against placebo instead of already approved vaccines, putting participants at risk and setting back timelines for getting vaccines to market and into patients who need them.
No, RFK Jr isn’t just demanding placebo control groups. Yes, we always have a control group. No, it’s not always placebo. Yes, it’s fine that it’s not always placebo. Not every study is designed with a placebo control because not every study can ethically have a placebo control group (a great example of this is HIV trials).
I’m all for making sure vaccines are safe. I quite literally do that for a living. This change is not going to do make vaccines safer. This will put people at risk during the research phase and cause additional vaccine hesitancy for vaccines that are already approved. This will increase the amount of money and time it takes to get a vaccine to market. Which can mean lives when you’re trying to help mitigate an outbreak (hi that’s me, I help with that).
2) If malaria vaccine studies - which can include actively exposing participants to malaria after vaccinating them - used a placebo, every placebo participant would get malaria. And they would have a shit time. And we would be putting them at risk for no reason when we have an approved vaccine we could use as control. And we’d have garbage data.
1) This moves the goalposts. Almost all vaccines are first tested against placebo, yes. And then when we update them - like flu shots that get a new adjuvant or the updated COVID shots - we use the already approved version as a control instead so that everyone in the study is protected and we’re comparing the vaccines to each other. This change shoved us back to only using placebos even though we have a way to protect everyone.
The gold standard is randomized controlled trials that are double blind so neither the observer nor the participant knows if they got vaccine or placebo. That way you help protect against any inadvertent bias in the results. The person who does the actual vaccine administration or the pharmacist who prepares it is sometimes unblinded and knows what it is because they have to but they aren’t allowed to tell anyone and if they do it’s a big deal.
We can rave like lunatics at stoplights instead of drinking together. One day at a time. We scream, we rage, we look at memes, we don’t let the bastards get us down.
Do no harm and take no shit
I managed HIV research trials before shifting into vaccine work and I cannot even tell you how quickly someone would get throat punched if they suggested using a placebo in an HIV trial.
Look into doing an accelerated bachelors in nursing program! You should have all the pre-reqs out of the way and you’d only need 12-16 months (depending on the program) to get your BSN and RN instead of another full two years.
The WIRED article says “This decision follows identification and documentation of personnel issues involving contract staff that compromised the facility’s safety culture, prompting this research pause” which can only be code for “someone wasn’t Christian enough” because in my experience working with the NIH labs in Frederick, you do not fuck around with their safety/security protocols, contract staff or otherwise.
He came to my middle school to do a reading dressed up like Shakespeare with a feather in his hat and everything and our class absolutely talked shit about him after he left. I ended up with a signed copy of the book and the feeling I had just met the nerdiest kid ever. I remember highlighting misspellings in the books and being very let down by the whole series.
He’s talking about age of majority, or the age you’re legally considered an adult, as opposed to age of consent. In most US states you’re legally considered an adult at 18, though there’s a few random states where it’s 19 or higher. I believe age of consent just applies to sex/marriage and I think is 16 in most US states.
My dad used to come home from work and yell out “where’s my sous chef?” I’d haul a chair over to the stove to stand on and we’d cook dinner together. He passed his love language of food on to me. He still calls me to share new recipes and drags me into the kitchen first thing when we go visit.
I was going to say do white uppers and dark lowers to let the white add vibrancy and openness but also add contrast. We had deep blue lowers and white wall open upper shelves in our last kitchen and it was gorgeous.
That hospital would not have accepted that unless someone rocked up with the paperwork to back it up. The EMT/paramedics I used to work with used to say that they wouldn’t follow a DNR tattoo encountered in the wild because it’d too much of a gray area.
The last time I did CPR we saved a 92/93 year old man who was a full code per policy because they couldn’t confirm the DNR status. His POA didn’t show up with any documentation of what he wanted until after we’d coded him for an hour and got him back and in the ICU. It wasn’t what he wanted. I have never been more devastated at work, that shift wrecked me for a while. Frankly harder than all the folks we couldn’t save.
Pair that with some pearl clutching from Susan Collins and we may be in business
I’m sorry, the car driving her to the hospital caught fire? So she was shot in the back by her partner and then the transport car caught on fire. But it was all “unintentional”. Uhhh
Ours flies year round and was ironed by Mother Nature as god intended
There was an uproar when that guy got dumped on Love is Blind because he’d spent the entire series saying he’d “never thought about it” to things like BLM, women’s rights, LGBTQ+ issues etc and he lived in Minneapolis during/after the murder of George Floyd, the fiancé who dumped him has a sibling in the LGBTQ+ crew, he was super into his church, etc. I could never decide if he actually never thought about stuff or if he was hiding it but either way, it’s a whole ass non-starter.
The Dark Crystal. The Skeksis-is (Skesisi?) were the stars of the recurring nightmare I had throughout my entire childhood until I was in college.
As a resident of the ocean edge of Washington state, it would take me 45 Freedom Hours one-way without stopping to drive to DC. I would absolutely march my ass all the way to the gates of the White House if it wasn’t so bloody complicated and time-consuming to get there, especially when there’s such good work going on locally that I can dig in to and support.
My favorite interaction was with a nurse at the health center of Christian university. She decided the appropriate way to ask if I was sexually active was to go with “Is your vagina a penis-free environment?” and my dumb ass went full pikachu face before responding with “In this exact moment or ever?” No the follow-up questions did not go any better 😂
As someone who works on the NIH’s drug research projects, particularly their vaccine -‘d infectious disease work, fuck all of the latest NIH/CDC/FDA updates. Just throw the whole fucking lot out. These people are going to get people killed.
My mom did WW in the early 00s (not that she needed it) and I remember boxes of crackers and cereal being labeled in sharpie with their point values and her trying to convince herself that low fat ricotta with unsweetened cocoa powder was a solid alternative to ice cream. She left that behind shortly after and has never looked back. The obsessive point counting was not good for her.
No me side-eyeing the Rabies study we did that compared a new vaccine to the existing vaccine because no one could reasonably justify having a placebo group https://media2.giphy.com/media/v1.Y2lkPTY1YjkxZmJlZnk4ZzNrOGxwNTB1YWxhOThlYmVtNXdsaXRrbXVodWw3dmZiZGZqaSZlcD12MV9naWZzX3NlYXJjaCZjdD1n/H5C8CevNMbpBqNqFjl/giphy.mp4
Double-blind is the norm, control groups are the norm. It’s that they’re forcing the control group to be placeboes for all vaccines, not just new vaccines. Vaccine research often uses currently approved or similar vaccines as the control group when testing updated vaccines because having a true placebo group would be unethical or because you want to compare the vaccines to each other. Forcing placebo controls for all vaccines changes the game in not a good way.
We tested all of the COVID vaccines before they were given to the general public. And then we kept testing them. And yes, more research gives more data that can confirm safety and efficacy or show things aren’t as good as initial research showed. That’s the purpose of initial phase research and post-approval research. We don’t just stop once things are approved.
Unblinding happens at the end of a study regardless of safety results. I’ve worked on plenty of studies that showed drugs were nothingburgers or not more effective than options already on the market. And that’s okay. That’s the point of research. We keep studying to find safe and effective options for people. But this will actively get in the way of that.
All med research is done with a control group, it’s just that not every control group is placebo because it doesn’t have to be or shouldn’t be (for ethical reasons or based on study design). Updated vaccines are often tested with existing vaccines as the control group instead of placebo. This forces us to test new vaccines against placebo instead of already approved vaccines, putting participants at risk and setting back timelines for getting vaccines to market and into patients who need them.
No, RFK Jr isn’t just demanding placebo control groups.
Yes, we always have a control group.
No, it’s not always placebo.
Yes, it’s fine that it’s not always placebo. Not every study is designed with a placebo control because not every study can ethically have a placebo control group (a great example of this is HIV trials).
I’m all for making sure vaccines are safe. I quite literally do that for a living. This change is not going to do make vaccines safer. This will put people at risk during the research phase and cause additional vaccine hesitancy for vaccines that are already approved. This will increase the amount of money and time it takes to get a vaccine to market. Which can mean lives when you’re trying to help mitigate an outbreak (hi that’s me, I help with that).
2) If malaria vaccine studies - which can include actively exposing participants to malaria after vaccinating them - used a placebo, every placebo participant would get malaria. And they would have a shit time. And we would be putting them at risk for no reason when we have an approved vaccine we could use as control. And we’d have garbage data.
1) This moves the goalposts. Almost all vaccines are first tested against placebo, yes. And then when we update them - like flu shots that get a new adjuvant or the updated COVID shots - we use the already approved version as a control instead so that everyone in the study is protected and we’re comparing the vaccines to each other. This change shoved us back to only using placebos even though we have a way to protect everyone.
The gold standard is randomized controlled trials that are double blind so neither the observer nor the participant knows if they got vaccine or placebo. That way you help protect against any inadvertent bias in the results. The person who does the actual vaccine administration or the pharmacist who prepares it is sometimes unblinded and knows what it is because they have to but they aren’t allowed to tell anyone and if they do it’s a big deal.
We can rave like lunatics at stoplights instead of drinking together. One day at a time. We scream, we rage, we look at memes, we don’t let the bastards get us down.
Do no harm and take no shit
I managed HIV research trials before shifting into vaccine work and I cannot even tell you how quickly someone would get throat punched if they suggested using a placebo in an HIV trial.
Look into doing an accelerated bachelors in nursing program! You should have all the pre-reqs out of the way and you’d only need 12-16 months (depending on the program) to get your BSN and RN instead of another full two years.
The WIRED article says “This decision follows identification and documentation of personnel issues involving contract staff that compromised the facility’s safety culture, prompting this research pause” which can only be code for “someone wasn’t Christian enough” because in my experience working with the NIH labs in Frederick, you do not fuck around with their safety/security protocols, contract staff or otherwise.