Drosophilamelanobastard
82903
2279
215
Upvote in 10 seconds or you will get over 35 CAG repeats in your HTT gene causing you kids to get Huntington's disease.
Mar 29, 2017 9:01 PM
Drosophilamelanobastard
82903
2279
215
Upvote in 10 seconds or you will get over 35 CAG repeats in your HTT gene causing you kids to get Huntington's disease.
TweakerTheBarbarian
As an IT person supporting bioinformaticians, I appreciate this.
OtroBarry
babycoolredhead
Me kids is fine.
SovietRusalka
I'm learning this right now!
Drosophilamelanobastard
* your
Roune
Not cool @OP. Not cool at all. BOTH my nonexistent children have Huntingtons disease.
erbiumyttriumytterbium
Damn enzymes! Can't trust 'em.
Drosophilamelanobastard
can't live with em...
acktually
Drosophilamelanobastard
Well there go my internet points...
SkeelosDad
Don't put that evil on me, Ricky Bobby!
WillDrug
Wow i understand this... Thanks to scinquisitor. Too bad his book isn't translated i don't think
Nahxela
What if I never have kids, got you there @OP
MoneybagsMcGee
Blackguytappinghead.gif
Drosophilamelanobastard
Fair enough.
SmokeMeAKipperIllBeBackForBreakfast
Score another for team No Kids!
imonewiththeforceandtheforceiswithme
Dontyouwishthatevilonmerickybobby.gif
Drosophilamelanobastard
no one likes when confused DNA polymerase comes to visit.
widgieqoio
i'm pregnant. you're a dick. take my upvote you jackass.
Drosophilamelanobastard
If neither you nor the father have Huntington's your kids are very unlikely to spontaneously get it.
widgieqoio
oh good! should i take my upvote back? lol jk
Theunholydownvoter
Thanks for educating people
dickbuttbeauty
Upvoting for the username and also yay genetics/genomics!
coolguy4206969
AgamemnonsMemes
Fucking polymerase, focus..
Drosophilamelanobastard
your droppin the ball man! wise up!
ShalomMyFriends
Are extra codons harmful or good mutations?
Drosophilamelanobastard
in this case it is bad because the protein gunks up the cells and kills them in an upsetting way.
HittingMyProstateMakesMeSneeze
This post is cancer.
Drosophilamelanobastard
Technically incorrect, it is a different kind of congenital disorder.
wheresmybottle
Huntington's. Lol. That shit is prob going to kill me. For real though it's like 50/50.
Drosophilamelanobastard
And thats why we must invest in stem cell research and CRISPR and other potential therapies.
CrisprCASrat
Pretty sure we will be able to fix this with crispr within 10 years
Drosophilamelanobastard
CRISPR is pretty damn cool, but genetic corrections in grown individuals is a long way off.
CrisprCASrat
I run a crispr lab, less than 10, maybe less than 5 years you will see a cure :)
Drosophilamelanobastard
Nice username btw, and thats neato burrito :)
Drosophilamelanobastard
maybe we could fiddle with Zygotes to snip out CAGs before they are even born.
Havok707
Immunity cat visited me already, thx.
Drosophilamelanobastard
You are free to go sir. Have a lovely evening.
cuttlefishsticks
Huntington's is a terrible disease. Destroys peoples' lives in the cruelest ways.
Drosophilamelanobastard
Oh yeah, not gonna play at nobility, posted this for points not awareness, but perhaps awareness will be a positive side effect.
Drosophilamelanobastard
Talked to some people who wanted to learn about the science behind it here. Maybe a young one will grow up to find a cure.
kungphu
thanks for your post wish I have seen it during my time in college
CentaurForDiseaseControl
Oh...
Mut3Panda
Fuck me I'm a sophomore in high school doing this shit what am I gonna do in college
bitchinmona
Literally the first three semesters are the hardest. Get past that and you'll actually love it.
kungphu
depend on your major, if you are doing science then that is just the tip of the iceberg you are about to run into
Mut3Panda
I am doing chemistry
NoMrBondIExpectYouToDie
Sophomore in college here. You'll survive.
frustwrited
HA JOKES ON YOU my kids already have huntington's disease...oh. *cries internally*
Drosophilamelanobastard
Good news, it usually doesn't manifest till age 40, bad news, your personality becomes irritable and depressive and you lose muscle control.
Nespadh
That's... heartbreaking :(
frustwrited
It was a joke, completely untrue, but it is heartbreaking. Which was my only response to this.
nobodyinpoortent
Drosophilamelanobastard
It's basically a cute animation explaining how people get a nasty mutation that causes loss of muscle control and death by age 60.
nobodyinpoortent
You kind of made it un-cute. I'm going to sad now. Or were you being facetious?
Drosophilamelanobastard
That is what it is, but the cute animation is meant to teach students about the disease not facetiously mock it.
Drosophilamelanobastard
https://www.youtube.com/watch?v=IuSaXiRVqg0 sauce. really great video on Huntington's causes, symptoms, diagnosis, treatment & pathology
CrimeBrulee
Look I don't want to do that, just tell me if that's actually how Huntington's happens.
Drosophilamelanobastard
Sometimes it is, and this is how it gets worse from one generation to the next. Idk if i can explain the nuances in 140 character chunks.
thedickpickjudge
Biotech majors unite!
ifartedwhilewatchingyourdog
I watched the whole video but I'm not the smartest guy around and didn't understand most of it. Still a neat watch.
Drosophilamelanobastard
Thats okay :) I'm glad you thought it was neat! I'm giving a presentation on this so any questions you ask would actually help me!
PresidentProTempore
I love how Wikipedia uses these videos to explain diseases
Drosophilamelanobastard
Thats where I found it! it is really effective
seeingsalty
That hit close to home, @OP. HD runs in my family.
Drosophilamelanobastard
i'm really sorry to hear that. Stem cell research looks promising... but it has a long ways to go.
thewhifflingtit
Consider not breeding and adopt.
thewhifflingtit
It doesn't need to run in your family. You could help in the prevention of the disease.
Drosophilamelanobastard
Get tested if you really want kids. If you personally don't have it there is no reason not to reproduce.
seeingsalty
No shit
kingmagnus22
I never upvoted so fast. I ain't risking that shit
Drosophilamelanobastard
best to be safe
kingmagnus22
I've met someone with Huntingtons. I wouldn't wish that on my worse enemy. *shudder*
Drosophilamelanobastard
oh yeah, it's heartbreaking watching someone you care about lose control of their minds and bodies :(
kingmagnus22
Yep and I definitely don't fuck around when it comes to my son
Drosophilamelanobastard
well if neither you nor your partner have it your son's chances are almost zero.
UnknownJD
Explanation?
Drosophilamelanobastard
Check out the vid https://www.youtube.com/watch?v=IuSaXiRVqg0
Barackrifle
Osmosis has really brightened up the medical field with their engaging videos. I'm enjoying them deeply.
Drosophilamelanobastard
Huntington's disease is a dominant neurodegenerative disease that causes loss of muscle control and mental deterioration. It is caused by (1
GenkiSaint
Please explain to me like I'm 5 why a polyQ track interspersed with CAA codons doesn't produce the disease phenotype of solely CAG repeats
[deleted]
[deleted]
Drosophilamelanobastard
First, that is not a question any 5 year old I have ever met would ask. Second, I believe that the misread has something to do with the
Drosophilamelanobastard
proofreading domain of DNA pol. Since a misplaced CAA wouldn't line up where a CAG would go DNA pol can catch it, but if it's a CAG
Drosophilamelanobastard
it looks okay enough to move on. Does that make any sense? Im not sure I understand you question or if I have the right answer even if I did
Drosophilamelanobastard
a mutation where you have too many CAG repeats in the HTT gene which leads to HTT proteins with too many glutamine amino acids. (2
Drosophilamelanobastard
the defective protein builds up in neurons in the brain and kills them (it isn't entirely clear how the toxicity works) (3
Drosophilamelanobastard
the more repeats you have the earlier your symptoms show up. for most it's around 40 with death within 10-20 years.
Djchoragos
Thanks! But what causes the proliferation in the first place? You may have answered already; on the hunt!
asrai86
So it's a really horrible thing to wish upon people's children? I'll upvote that
UnknownJD
I love learning new things. Thank you!
asspickle
you sound smart. sometimes i stick pickles up my ass.
BigFag
nerd