DuffMan000
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Freakonomics
Stephen dubner explains 'the hidden side of everything' from an economist's point of view on topics ranging from 'should tipping be banned?' to 'weed vs alcohol, which is more dangerous?'
Star Talk
Probably my favorite on the list, Dr. Neil Tyson (black science man) explains why the universe be like it do. You can sometimes catch white science man (bill nye) on here too
Serial
If you didn't hear about serial in one way or another... WTF IS WRONG WITH YOU? What are u stupid or somethin? TAKE YER MAIL SHIMP ASS SOMEWHERE AND LISTEN TO IT. NAO.
Planet money
Interest short podcasts (15ish min) about money. Might sound a bit dry but these are actually interesting news stories about money matters.
Radiolab
Snap Judgement
Glynn washington hosted, 'story telling with a beat' I will be honest with you, this one is like 50/50 some are great and some I just cant sit through. But hey its free and the stories that are good are really entertaining.
Stuff you should know
Again, this one can be kind of dry at times but these guys have more episodes out there than your mom has former clients. These two guys explain pretty much every frikken thing
TED Radio hour
The world famous TED talks in radio form with interviews with the speakers thrown in. Really interesting talks about Technology Entertainment and Design. (thats what it fuckin stands for you casual)
This american life
I LOVE AMERIKA! One of the few podcasts consistently in the top 5 most downloaded these guys always have good topics. Definitely recommend
Wait wait don't tell me!
This one is like an old school game show and pretty goddamned funny if you ask me. Play along and shout at your radio like me while you drive! You win!
dianasbananas
how could weed possibly be more dangerous than alcohol
DuffMan000
that episode was a popular one. the premise was, if both substances were discovered tomorrow, how would we react?? which would be banned?